confOrganiser.com - Work: STUDYING OF THE LIPOPHILICITY AND TOXICITY OF DIPHENYLACETAMIDE DERIVATIVES

STUDYING OF THE LIPOPHILICITY AND TOXICITY OF DIPHENYLACETAMIDE DERIVATIVES

1. Suzana Apostolov, Univerzitet u Novom Sadu, Prirodno-matematički fakultet, Serbia
2. Đenđi Vaštag, Serbia
3. Borko Matijević, Prirodno-matematički fakultet, Departman za hemiju, biohemiju i zaštitu životne sredine, Serbia
4. Gorana Mrđan, Prirodno-matematički fakultet, Univeritet u Novom Sadu, Serbia

Modern approach in the study of biologically active compounds includes the establishment of relationships between molecular structure, physicochemical properties and the behavior which studied compound can manifest in the biological medium. These examinantions are performed in the early stages of the design of future bioactive agent and require the knowledge of molecular descriptors that can point to its biological activity, including lipophilicity occupies a key position. For the series of diphenylacetamide derivatives lipophilicity is determined experimentally, by thin layer chromatography on reversed phase (RP TLC18 F254s), in mixtures of water and various organic modifiers and computationally, by using the relevant software packets. In order to estimate the potential acute toxicity of the tested diphenylacetamide derivatives, their effective concentrations, EC50, on the selected test organisms have been determined. Experimentally determined lipophilicity (RM0 and m) is correlated with a standard measure of lipophilicity (log P), as well as with the selected parameters of toxicity. Thus it has been found that thin layer chromatography on reversed phase can be used reliably for describing the lipophilicity and for the evaluation of the toxic effects of diphenylacetamide derivatives.

Key words: difenilacetamidi; RP TLC; log P; toksičnost

Thematic field: SIMPOZIJUM B - Biomaterijali i nanomedicina

Date: 14.07.2017.

Contemporary Materials 2017 - Savremeni Materijali

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